InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG5

Summary

InnateDB Protein

IDBP-94858.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG5

Protein Name

ATG5 autophagy related 5 homolog (S. cerevisiae)

Synonyms

APG5; APG5-LIKE; APG5L; ASP; hAPG5;

Species

Homo sapiens

Ensembl Protein

ENSP00000358072

InnateDB Gene

IDBG-94856 (ATG5)

Protein Structure

UniProt Annotation

Function

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma- induced autophagic cell death by interacting with FADD.

Subcellular Localization

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	60 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0001974	blood vessel remodeling
GO:0002739	regulation of cytokine secretion involved in immune response
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0009620	response to fungus
GO:0031397	negative regulation of protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0039689	negative stranded viral RNA replication
GO:0042311	vasodilation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043687	post-translational protein modification
GO:0045087	innate immune response (InnateDB)
GO:0048840	otolith development
GO:0055015	ventricular cardiac muscle cell development
GO:0060047	heart contraction
GO:1902017	regulation of cilium assembly