InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF13C

Summary

InnateDB Protein

IDBP-9493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF13C

Protein Name

tumor necrosis factor receptor superfamily, member 13C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000291232

InnateDB Gene

IDBG-9491 (TNFRSF13C)

Protein Structure

UniProt Annotation

Function

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269PubMed:11591325, ECO:0000269PubMed:12387744}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Immunodeficiency, common variable, 4 (CVID4) [MIM:613494]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269PubMed:19666484}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001782	B cell homeostasis
GO:0002636	positive regulation of germinal center formation
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0031296	B cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0050776	regulation of immune response