InnateDB Protein
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IDBP-95163.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTAFR
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Protein Name
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platelet-activating factor receptor
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Synonyms
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PAFR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362965
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InnateDB Gene
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IDBG-95161 (PTAFR)
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Protein Structure
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Function |
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO:0000269PubMed:1281995, ECO:0000269PubMed:1374385, ECO:0000269PubMed:1656963, ECO:0000269PubMed:1657923}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:1374385}; Multi-pass membrane protein {ECO:0000269PubMed:1374385}.
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Disease Associations |
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Tissue Specificity |
Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO:0000269PubMed:1281995, ECO:0000269PubMed:1656963, ECO:0000269PubMed:1657923}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR002282
Platelet-activating factor receptor
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
PR01153
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P25105
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PhosphoSite |
PhosphoSite-P25105
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5724
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UniGene |
Hs.77542
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RefSeq |
NP_001158195
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HUGO |
HGNC:9582
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OMIM |
173393
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CCDS |
CCDS318
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HPRD |
01422
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IMGT |
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EMBL |
AK290240
AY275466
BC013816
BC063000
BT009801
CH471059
D10202
L07334
M76674
M80436
M88177
S52624
S56396
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GenPept |
AAA60001
AAA60002
AAA60108
AAA60214
AAB24695
AAB25755
AAH13816
AAH63000
AAP32298
AAP88803
BAA01050
BAF82929
EAX07711
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