InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTAFR

Summary

InnateDB Gene

IDBG-95161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTAFR

Gene Name

platelet-activating factor receptor

Synonyms

PAFR

Species

Homo sapiens

Ensembl Gene

ENSG00000169403

Encoded Proteins

IDBP-95163

platelet-activating factor receptor

IDBP-95165

platelet-activating factor receptor

IDBP-602519

platelet-activating factor receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 11309383

PTAFR is involved in G-protein-independent activation of TYK2.

Entrez Gene

Summary

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:28147166-28193936

Strand

Reverse strand

Band

p35.3

Transcripts

ENST00000373857	ENSP00000362965
ENST00000305392	ENSP00000301974
ENST00000539896	ENSP00000442658

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001875	lipopolysaccharide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004992	platelet activating factor receptor activity
GO:0005543	phospholipid binding

Biological Process

GO:0001816	cytokine production
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032959	inositol trisphosphate biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0048015	phosphatidylinositol-mediated signaling
GO:0060333	interferon-gamma-mediated signaling pathway