Version 5.4
Homo sapiens Protein: PTAFR
Summary
InnateDB Protein IDBP-95165.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTAFR
Protein Name platelet-activating factor receptor
Synonyms PAFR;
Species Homo sapiens
Ensembl Protein ENSP00000301974
InnateDB Gene IDBG-95161 (PTAFR)
Protein Structure
UniProt Annotation
Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO:0000269PubMed:1281995, ECO:0000269PubMed:1374385, ECO:0000269PubMed:1656963, ECO:0000269PubMed:1657923}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:1374385}; Multi-pass membrane protein {ECO:0000269PubMed:1374385}.
Disease Associations
Tissue Specificity Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO:0000269PubMed:1281995, ECO:0000269PubMed:1656963, ECO:0000269PubMed:1657923}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004992 platelet activating factor receptor activity
GO:0005543 phospholipid binding
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048015 phosphatidylinositol-mediated signaling
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002282 Platelet-activating factor receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR01153
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P25105
PhosphoSite PhosphoSite-P25105
TrEMBL
UniProt Splice Variant
Entrez Gene 5724
UniGene Hs.77542
RefSeq
HUGO HGNC:9582
OMIM 173393
CCDS CCDS318
HPRD 01422
IMGT
EMBL AK290240 AY275466 BC013816 BC063000 BT009801 CH471059 D10202 L07334 M76674 M80436 M88177 S52624 S56396
GenPept AAA60001 AAA60002 AAA60108 AAA60214 AAB24695 AAB25755 AAH13816 AAH63000 AAP32298 AAP88803 BAA01050 BAF82929 EAX07711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca