Version 5.4
Homo sapiens Protein: CDC40
Summary
InnateDB Protein IDBP-95226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC40
Protein Name cell division cycle 40 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357928
InnateDB Gene IDBG-95222 (CDC40)
Protein Structure
UniProt Annotation
Function Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. {ECO:0000269PubMed:9830021}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9830021}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60508
PhosphoSite PhosphoSite-O60508
TrEMBL Q5SRM9
UniProt Splice Variant
Entrez Gene 51362
UniGene Hs.612969
RefSeq
HUGO HGNC:17350
OMIM 605585
CCDS CCDS5081
HPRD 05721
IMGT
EMBL AF015044 AF038392 AF061241 AK314601 AL445068 AL671518 BC117145 BC126114
GenPept AAC25166 AAC39730 AAD01552 AAI17146 AAI26115 BAG37172 CAI13322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca