Homo sapiens Gene: CDC40
Summary
InnateDB Gene IDBG-95222.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC40
Gene Name cell division cycle 40 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168438
Encoded Proteins
cell division cycle 40 homolog (S. cerevisiae)
cell division cycle 40 homolog (S. cerevisiae)
cell division cycle 40 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:110180141-110254275
Strand Forward strand
Band q21
Transcripts
ENST00000368932 ENSP00000357928
ENST00000368930 ENSP00000357926
ENST00000307731 ENSP00000304370
ENST00000453107
ENST00000431461
ENST00000606893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
mRNA 3'-end processing pathway
RNA Polymerase II Transcription Termination pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O60508
TrEMBL Q5SRM9
UniProt Splice Variant
Entrez Gene 51362
UniGene Hs.428147 Hs.612969
RefSeq NM_015891
HUGO HGNC:17350
OMIM 605585
CCDS CCDS5081
HPRD 05721
IMGT
EMBL AF015044 AF038392 AF061241 AK314601 AL445068 AL671518 BC117145 BC126114
GenPept AAC25166 AAC39730 AAD01552 AAI17146 AAI26115 BAG37172 CAI13322
RNA Seq Atlas 51362