InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RCC1

Summary

InnateDB Protein

IDBP-95239.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCC1

Protein Name

regulator of chromosome condensation 1

Synonyms

CHC1; RCC1-I; SNHG3-RCC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000362937

InnateDB Gene

IDBG-95231 (RCC1)

Protein Structure

UniProt Annotation

Function

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. {ECO:0000269PubMed:1944575}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17435751}. Cytoplasm {ECO:0000269PubMed:17435751}. Note=Becomes dispersed throughout the cytoplasm during mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 104 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	104 [view]
Protein-Protein	104 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005087	Ran guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding
GO:0042393	histone binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0007052	mitotic spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007088	regulation of mitosis
GO:0016032	viral process
GO:0032316	regulation of Ran GTPase activity
GO:0032853	positive regulation of Ran GTPase activity
GO:0051225	spindle assembly