InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THRAP3

Summary

InnateDB Protein

IDBP-96336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THRAP3

Protein Name

thyroid hormone receptor associated protein 3

Synonyms

TRAP150;

Species

Homo sapiens

Ensembl Protein

ENSP00000346634

InnateDB Gene

IDBG-96334 (THRAP3)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. {ECO:0000269PubMed:20123736, ECO:0000269PubMed:20932480, ECO:0000269PubMed:22424773, ECO:0000269PubMed:23525231}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20123736, ECO:0000269PubMed:23525231}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10198638}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	108 [view]
Protein-Protein	104 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809	vitamin D receptor binding
GO:0044822	poly(A) RNA binding
GO:0046966	thyroid hormone receptor binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048026	positive regulation of mRNA splicing, via spliceosome
GO:0048255	mRNA stabilization