Version 5.4
Homo sapiens Protein: CSF3R
Summary
InnateDB Protein IDBP-96383.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF3R
Protein Name colony stimulating factor 3 receptor (granulocyte)
Synonyms CD114; GCSFR;
Species Homo sapiens
Ensembl Protein ENSP00000362196
InnateDB Gene IDBG-96377 (CSF3R)
Protein Structure
UniProt Annotation
Function Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. {ECO:0000269PubMed:7514305}.
Subcellular Localization Isoform 2: Secreted {ECO:0000305}.Cell membrane; Single-pass type I membrane protein.
Disease Associations Hereditary neutrophilia (NEUTROPHILIA) [MIM:162830]: A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood. {ECO:0000269PubMed:19620628}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 29 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR010457 Immunoglobulin C2-set-like, ligand-binding
PFAM PF00041
PF01108
PF06328
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99062
PhosphoSite PhosphoSite-Q99062
TrEMBL E9PK56
UniProt Splice Variant
Entrez Gene 1441
UniGene Hs.524517
RefSeq NP_758519
HUGO HGNC:2439
OMIM 138971
CCDS CCDS412
HPRD 00737
IMGT
EMBL AC119675 AY148100 BC053585 M59818 M59819 M59820 S71484 X55720 X55721
GenPept AAA63176 AAA63177 AAA63178 AAB20660 AAH53585 AAN05790 CAA39252 CAA39253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca