Homo sapiens Gene: CSF3R
Summary
InnateDB Gene IDBG-96377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF3R
Gene Name colony stimulating factor 3 receptor (granulocyte)
Synonyms CD114; GCSFR;
Species Homo sapiens
Ensembl Gene ENSG00000119535
Encoded Proteins
colony stimulating factor 3 receptor (granulocyte)
colony stimulating factor 3 receptor (granulocyte)
colony stimulating factor 3 receptor (granulocyte)
colony stimulating factor 3 receptor (granulocyte)
colony stimulating factor 3 receptor (granulocyte)
colony stimulating factor 3 receptor (granulocyte)
colony stimulating factor 3 receptor (granulocyte)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:36466043-36483278
Strand Reverse strand
Band p34.3
Transcripts
ENST00000373103 ENSP00000362195
ENST00000373106 ENSP00000362198
ENST00000373104 ENSP00000362196
ENST00000331941 ENSP00000332180
ENST00000361632 ENSP00000355406
ENST00000487540
ENST00000484762
ENST00000466138
ENST00000464465 ENSP00000435218
ENST00000464365
ENST00000480825
ENST00000469380
ENST00000489551
ENST00000526980
ENST00000533491 ENSP00000431639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 29 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0030593 neutrophil chemotaxis
GO:0097186 amelogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
Pathways in cancer pathway
INOH
JAK STAT pathway and regulation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524517
RefSeq NM_000760 NM_156039 NM_172313 XM_005270493
HUGO
OMIM
CCDS CCDS412 CCDS413 CCDS414
HPRD 00737
IMGT
EMBL
GenPept
RNA Seq Atlas