InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARG1

Summary

InnateDB Protein

IDBP-96500.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARG1

Protein Name

arginase, liver

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349446

InnateDB Gene

IDBG-96496 (ARG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16141327}.

Disease Associations

Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269PubMed:1463019, ECO:0000269PubMed:7649538}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004053	arginase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000050	urea cycle
GO:0001889	liver development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006525	arginine metabolic process
GO:0006527	arginine catabolic process
GO:0007565	female pregnancy
GO:0009611	response to wounding
GO:0009635	response to herbicide
GO:0010042	response to manganese ion
GO:0010043	response to zinc ion
GO:0010269	response to selenium ion
GO:0010963	regulation of L-arginine import
GO:0014075	response to amine
GO:0030324	lung development
GO:0032496	response to lipopolysaccharide
GO:0032964	collagen biosynthetic process
GO:0033189	response to vitamin A
GO:0033197	response to vitamin E
GO:0034641	cellular nitrogen compound metabolic process
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0043434	response to peptide hormone
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046686	response to cadmium ion
GO:0048545	response to steroid hormone
GO:0048678	response to axon injury
GO:0051597	response to methylmercury
GO:0060056	mammary gland involution
GO:0060135	maternal process involved in female pregnancy
GO:0070207	protein homotrimerization
GO:0070301	cellular response to hydrogen peroxide
GO:0071222	cellular response to lipopolysaccharide
GO:0071353	cellular response to interleukin-4
GO:0071377	cellular response to glucagon stimulus
GO:0071549	cellular response to dexamethasone stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome