|Homo sapiens Gene: ARG1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||arginase, liver|
|Useful resources||Stemformatics EHFPI ImmGen|
ARG1 expression induced by intracellular pathogens in mouse classically activated macrophages (CAMs) through the TLR pathway, suppressing nitric oxide production and thwarting effective immunity independent of the STAT6 pathway.
PI3K/PTEN-regulated extracellular ARG1 acts as a paracrine regulator of inflammation and immunity. Demonstrated in mice.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
|Genomic Location||Chromosome 6:131573144-131584332|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
Arginine and proline metabolism pathway
Arginine Proline metabolism pathway
ATF-2 transcription factor network
IL4-mediated signaling events
|UniProt Splice Variant|
|RNA Seq Atlas|