InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTGF

Summary

InnateDB Protein

IDBP-96633.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTGF

Protein Name

connective tissue growth factor

Synonyms

CCN2; HCS24; IGFBP8; NOV2;

Species

Homo sapiens

Ensembl Protein

ENSP00000356954

InnateDB Gene

IDBG-96631 (CTGF)

Protein Structure

UniProt Annotation

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. {ECO:0000269PubMed:10614647, ECO:0000269PubMed:12553878}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. {ECO:0000269PubMed:1756408}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001558	regulation of cell growth
GO:0001894	tissue homeostasis
GO:0001934	positive regulation of protein phosphorylation
GO:0006260	DNA replication
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0009611	response to wounding
GO:0009749	response to glucose
GO:0010260	organ senescence
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0016477	cell migration
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0032330	regulation of chondrocyte differentiation
GO:0032355	response to estradiol
GO:0032967	positive regulation of collagen biosynthetic process
GO:0034059	response to anoxia
GO:0035556	intracellular signal transduction
GO:0035988	chondrocyte proliferation
GO:0043200	response to amino acid
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434	response to peptide hormone
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045597	positive regulation of cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0050867	positive regulation of cell activation
GO:0051385	response to mineralocorticoid
GO:0051496	positive regulation of stress fiber assembly
GO:0060401	cytosolic calcium ion transport
GO:0060452	positive regulation of cardiac muscle contraction
GO:0060548	negative regulation of cell death
GO:0061448	connective tissue development
GO:0070278	extracellular matrix constituent secretion
GO:0070318	positive regulation of G0 to G1 transition
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070542	response to fatty acid
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00093
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00214
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt