InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGF2BP3

Summary

InnateDB Protein

IDBP-9679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2BP3

Protein Name

insulin-like growth factor 2 mRNA binding protein 3

Synonyms

CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3;

Species

Homo sapiens

Ensembl Protein

ENSP00000258729

InnateDB Gene

IDBG-9675 (IGF2BP3)

Protein Structure

UniProt Annotation

Function

RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta- actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269PubMed:16541107, ECO:0000269PubMed:23640942}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Disease Associations

Tissue Specificity

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. {ECO:0000269PubMed:10525192, ECO:0000269PubMed:12161597, ECO:0000269PubMed:15644775, ECO:0000269PubMed:16049158, ECO:0000269PubMed:16814207, ECO:0000269PubMed:17192788, ECO:0000269PubMed:9178771, ECO:0000269PubMed:9891060}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006412	translation
GO:0009653	anatomical structure morphogenesis
GO:0010467	gene expression
GO:0017148	negative regulation of translation
GO:0042035	regulation of cytokine biosynthetic process
GO:0051028	mRNA transport