Homo sapiens Gene: IGF2BP3
Summary
InnateDB Gene IDBG-9675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF2BP3
Gene Name insulin-like growth factor 2 mRNA binding protein 3
Synonyms CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3;
Species Homo sapiens
Ensembl Gene ENSG00000136231
Encoded Proteins
insulin-like growth factor 2 mRNA binding protein 3
insulin-like growth factor 2 mRNA binding protein 3
insulin-like growth factor 2 mRNA binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5\' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23310209-23470467
Strand Reverse strand
Band p15.3
Transcripts
ENST00000258729 ENSP00000258729
ENST00000421467 ENSP00000395936
ENST00000498363
ENST00000467592
ENST00000497563
ENST00000480547
ENST00000495009
ENST00000468263
ENST00000492771
ENST00000479504
ENST00000466809
ENST00000491719
ENST00000465058
ENST00000469723
ENST00000474105
ENST00000476938
ENST00000468005
ENST00000619562 ENSP00000480267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0006412 translation
GO:0009653 anatomical structure morphogenesis
GO:0010467 gene expression
GO:0017148 negative regulation of translation
GO:0042035 regulation of cytokine biosynthetic process
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.700696
RefSeq NM_006547 XM_006715638 XM_006715639
HUGO
OMIM
CCDS CCDS5382
HPRD 16306
IMGT
EMBL
GenPept
RNA Seq Atlas