Version 5.4
Homo sapiens Protein: ALDH8A1
Summary
InnateDB Protein IDBP-96816.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH8A1
Protein Name aldehyde dehydrogenase 8 family, member A1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000325473
InnateDB Gene IDBG-96808 (ALDH8A1)
Protein Structure
UniProt Annotation
Function Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). {ECO:0000269PubMed:11007799}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney. {ECO:0000269PubMed:11007799}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001758 retinal dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0008152 metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase
PFAM PF00171
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2A2
PhosphoSite PhosphoSite-Q9H2A2
TrEMBL
UniProt Splice Variant
Entrez Gene 64577
UniGene Hs.486520
RefSeq
HUGO HGNC:15471
OMIM 606467
CCDS
HPRD 06974
IMGT
EMBL AF303134 AK222848 AK290784 AK298325 AL021939 AL445190 BC113862 BC114473 CH471051
GenPept AAG42417 AAI13863 AAI14474 BAD96568 BAF83473 BAH12757 CAI20305 CAI20306 CAI95158 CAI95159 EAW47985 EAW47986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca