Homo sapiens Gene: ALDH8A1
Summary
InnateDB Gene IDBG-96808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH8A1
Gene Name aldehyde dehydrogenase 8 family, member A1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118514
Encoded Proteins
aldehyde dehydrogenase 8 family, member A1
aldehyde dehydrogenase 8 family, member A1
aldehyde dehydrogenase 8 family, member A1
aldehyde dehydrogenase 8 family, member A1
aldehyde dehydrogenase 8 family, member A1
aldehyde dehydrogenase 8 family, member A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:134917390-134950122
Strand Reverse strand
Band q23.3
Transcripts
ENST00000265605 ENSP00000265605
ENST00000367847 ENSP00000356821
ENST00000367845 ENSP00000356819
ENST00000349305 ENSP00000325473
ENST00000460753 ENSP00000437161
ENST00000534012 ENSP00000435297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001758 retinal dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0008152 metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 64577
UniGene Hs.486520
RefSeq NM_001193480 NM_022568 NM_170771
HUGO HGNC:15471
OMIM 606467
CCDS CCDS5171 CCDS5172 CCDS55057
HPRD 06974
IMGT
EMBL
GenPept
RNA Seq Atlas 64577