InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPL

Summary

InnateDB Protein

IDBP-97405.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPL

Protein Name

myeloproliferative leukemia virus oncogene

Synonyms

C-MPL; CD110; MPLV; THCYT2; TPOR;

Species

Homo sapiens

Ensembl Protein

ENSP00000361548

InnateDB Gene

IDBG-97403 (MPL)

Protein Structure

UniProt Annotation

Function

Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]: Disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.Thrombocythemia 2 (THCYT2) [MIM:601977]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. {ECO:0000269PubMed:14764528, ECO:0000269PubMed:23441089}. Note=The disease is caused by mutations affecting the gene represented in this entry.Myelofibrosis with myeloid metaplasia (MMM) [MIM:254450]: A chronic myeloproliferative disorder characterized by replacement of the bone marrow by fibrous tissue, extramedullary hematopoiesis, anemia, leukoerythroblastosis and hepatosplenomegaly. {ECO:0000269PubMed:16834459, ECO:0000269PubMed:16868251}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030168	platelet activation
GO:0032642	regulation of chemokine production
GO:0048872	homeostasis of number of cells