Version 5.4
Homo sapiens Protein: TSPAN1
Summary
InnateDB Protein IDBP-98083.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN1
Protein Name tetraspanin 1
Synonyms NET1; TM4C; TM4SF;
Species Homo sapiens
Ensembl Protein ENSP00000361072
InnateDB Gene IDBG-98081 (TSPAN1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:19508227}; Multi-pass membrane protein {ECO:0000269PubMed:19508227}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015403 thiamine uptake transmembrane transporter activity
Biological Process
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0045807 positive regulation of endocytosis
GO:0050821 protein stabilization
GO:0071934 thiamine transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60635
PhosphoSite PhosphoSite-O60635
TrEMBL
UniProt Splice Variant
Entrez Gene 10103
UniGene Hs.38972
RefSeq NP_005718
HUGO HGNC:20657
OMIM 613170
CCDS CCDS530
HPRD 18232
IMGT
EMBL AF054838 AF065388 AF133425 AK313774 AL672043 BC007290 BC013404 CH471059
GenPept AAC17119 AAC69714 AAF08364 AAH07290 AAH13404 BAG36512 CAH72468 EAX06938 EAX06939 EAX06940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca