Version 5.4
Homo sapiens Protein: FAAH
Summary
InnateDB Protein IDBP-98118.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAAH
Protein Name fatty acid amide hydrolase
Synonyms FAAH-1; PSAB;
Species Homo sapiens
Ensembl Protein ENSP00000243167
InnateDB Gene IDBG-98116 (FAAH)
Protein Structure
UniProt Annotation
Function Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. {ECO:0000269PubMed:17015445}.
Subcellular Localization Endomembrane system {ECO:0000269PubMed:17015445}; Single-pass membrane protein {ECO:0000269PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
Disease Associations
Tissue Specificity Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. {ECO:0000269PubMed:17015445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0017064 fatty acid amide hydrolase activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0009062 fatty acid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
Protein Structure and Domains
PDB ID
InterPro IPR000120 Amidase
IPR015830 Amidase, fungi type
IPR023631 Amidase signature domain
PFAM PF01425
PRINTS
PIRSF PIRSF001221
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00519
PhosphoSite PhosphoSite-O00519
TrEMBL
UniProt Splice Variant
Entrez Gene 2166
UniGene Hs.720143
RefSeq NP_001432
HUGO HGNC:3553
OMIM 602935
CCDS CCDS535
HPRD 04244
IMGT
EMBL AF098010 AF098011 AF098012 AF098013 AF098014 AF098015 AF098016 AF098017 AF098018 AF098019 AL122001 AY842444 BC093632 BC110404 BC111941 CH471059 U82535
GenPept AAB58505 AAD13768 AAH93632 AAI10405 AAI11942 AAV88095 CAI21960 EAX06912 EAX06919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca