InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VIP

Summary

InnateDB Protein

IDBP-98131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIP

Protein Name

vasoactive intestinal peptide

Synonyms

PHM27;

Species

Homo sapiens

Ensembl Protein

ENSP00000356213

InnateDB Gene

IDBG-98129 (VIP)

Protein Structure

UniProt Annotation

Function

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. {ECO:0000269PubMed:15013843}.PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. {ECO:0000269PubMed:15013843}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007589	body fluid secretion
GO:0007611	learning or memory
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0043267	negative regulation of potassium ion transport
GO:0045732	positive regulation of protein catabolic process
GO:0045909	positive regulation of vasodilation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051930	regulation of sensory perception of pain
GO:0060406	positive regulation of penile erection