InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MKNK1

Summary

InnateDB Protein

IDBP-98145.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKNK1

Protein Name

MAP kinase interacting serine/threonine kinase 1

Synonyms

MNK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000361013

InnateDB Gene

IDBG-98137 (MKNK1)

Protein Structure

UniProt Annotation

Function

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap. {ECO:0000269PubMed:11463832, ECO:0000269PubMed:15350534, ECO:0000269PubMed:9155018, ECO:0000269PubMed:9878069}.

Subcellular Localization

Isoform 2: Cytoplasm.Isoform 3: Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15350534}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009103	lipopolysaccharide biosynthetic process
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt