InnateDB Protein
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IDBP-98154.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FBXO5
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Protein Name
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F-box protein 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356210
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InnateDB Gene
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IDBG-98150 (FBXO5)
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Protein Structure
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Function |
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000269PubMed:11988738, ECO:0000269PubMed:16921029}.
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Subcellular Localization |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
55
[view]
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Protein-Protein |
50
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0000083
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regulation of transcription involved in G1/S transition of mitotic cell cycle
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GO:0000278
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mitotic cell cycle
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GO:0007091
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metaphase/anaphase transition of mitotic cell cycle
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GO:0007346
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regulation of mitotic cell cycle
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0060565
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inhibition of mitotic anaphase-promoting complex activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR001810
F-box domain
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PFAM |
PF00646
PF12937
PF13013
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PRINTS |
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PIRSF |
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SMART |
SM00256
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKT4
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PhosphoSite |
PhosphoSite-Q9UKT4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26271
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UniGene |
Hs.713801
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RefSeq |
NP_001135994
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HUGO |
HGNC:13584
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OMIM |
606013
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CCDS |
CCDS47501
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HPRD |
09348
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IMGT |
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EMBL |
AF129535
AK055221
AL080276
AY079515
BC018905
CH471051
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GenPept |
AAF04469
AAH18905
AAL86610
BAG51487
CAI18894
CAI18895
EAW47719
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