InnateDB Protein
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IDBP-98249.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TIAM2
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Protein Name
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T-cell lymphoma invasion and metastasis 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000275246
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InnateDB Gene
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IDBG-98237 (TIAM2)
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Protein Structure
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Function |
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269PubMed:10512681}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. {ECO:0000269PubMed:10512681}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005057
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receptor signaling protein activity
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GO:0005085
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guanyl-nucleotide exchange factor activity
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GO:0005089
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Rho guanyl-nucleotide exchange factor activity
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Biological Process |
GO:0007264
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small GTPase mediated signal transduction
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GO:0032321
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positive regulation of Rho GTPase activity
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GO:0035023
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regulation of Rho protein signal transduction
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GO:0043065
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positive regulation of apoptotic process
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0051056
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regulation of small GTPase mediated signal transduction
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000219
Dbl homology (DH) domain
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PFAM |
PF00621
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PRINTS |
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PIRSF |
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SMART |
SM00325
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IVF5
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PhosphoSite |
PhosphoSite-Q8IVF5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26230
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UniGene |
Hs.739388
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RefSeq |
NP_001010927
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HUGO |
HGNC:11806
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OMIM |
604709
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CCDS |
CCDS34559
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HPRD |
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IMGT |
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EMBL |
AB095936
AF120323
AF120324
AK125459
AL122086
AL139101
AL355343
AL596202
BC066979
BC137275
CH471051
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GenPept |
AAF05900
AAF05901
AAH66979
AAI37276
BAC23112
BAC86170
CAB59259
EAW47693
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