Version 5.4
Homo sapiens Protein: WTAP
Summary
InnateDB Protein IDBP-98562.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WTAP
Protein Name Wilms tumor 1 associated protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351141
InnateDB Gene IDBG-98560 (WTAP)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. {ECO:0000269PubMed:12444081, ECO:0000269PubMed:17088532, ECO:0000269PubMed:17095724, ECO:0000269PubMed:24316715, ECO:0000269PubMed:24407421}.
Subcellular Localization Nucleus, nucleolus. Nucleus speckle.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:11001926}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0007049 cell cycle
GO:0008380 RNA splicing
GO:0080009 mRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0036396 MIS complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15007
PhosphoSite PhosphoSite-Q15007
TrEMBL Q6AHX7
UniProt Splice Variant
Entrez Gene 9589
UniGene
RefSeq NP_004897
HUGO HGNC:16846
OMIM 605442
CCDS CCDS5266
HPRD 09259
IMGT
EMBL AF374416 AJ276706 AK127822 AL135914 AL583911 BC000383 BC004432 BC069192 CH471051 CR627456 D14661
GenPept AAH00383 AAH04432 AAH69192 AAK54764 BAA03495 BAG54579 CAC10188 CAC29495 CAH10537 CAI21848 CAI21849 EAW47622 EAW47624 EAW47625

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca