InnateDB Protein
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IDBP-98646.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZCCHC11
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Protein Name
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zinc finger, CCHC domain containing 11
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Synonyms
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PAPD3; TUT4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348063
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InnateDB Gene
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IDBG-98638 (ZCCHC11)
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Protein Structure
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Function |
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. {ECO:0000269PubMed:16643855, ECO:0000269PubMed:19703396}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q5TAX3
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TrEMBL |
X6R5G7
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UniProt Splice Variant |
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Entrez Gene |
23318
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UniGene |
Hs.717765
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RefSeq |
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HUGO |
HGNC:28981
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OMIM |
613692
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CCDS |
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HPRD |
15700
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IMGT |
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EMBL |
AL138849
AL513218
AL591167
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GenPept |
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