InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZCCHC11

Summary

InnateDB Gene

IDBG-98638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZCCHC11

Gene Name

zinc finger, CCHC domain containing 11

Synonyms

PAPD3; TUT4

Species

Homo sapiens

Ensembl Gene

ENSG00000134744

Encoded Proteins

IDBP-98640

zinc finger, CCHC domain containing 11

IDBP-98642

zinc finger, CCHC domain containing 11

IDBP-98646

zinc finger, CCHC domain containing 11

IDBP-602006

zinc finger, CCHC domain containing 11

IDBP-587899

zinc finger, CCHC domain containing 11

IDBP-586789

zinc finger, CCHC domain containing 11

IDBP-596059

zinc finger, CCHC domain containing 11

IDBP-585682

zinc finger, CCHC domain containing 11

IDBP-583620

zinc finger, CCHC domain containing 11

IDBP-587443

zinc finger, CCHC domain containing 11

IDBP-590542

zinc finger, CCHC domain containing 11

IDBP-584077

zinc finger, CCHC domain containing 11

IDBP-583548

zinc finger, CCHC domain containing 11

IDBP-593276

zinc finger, CCHC domain containing 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:52408282-52553487

Strand

Reverse strand

Band

p32.3

Transcripts

ENST00000371544	ENSP00000360599
ENST00000257177	ENSP00000257177
ENST00000371541
ENST00000355809	ENSP00000348063
ENST00000474453	ENSP00000433711
ENST00000466440
ENST00000494469	ENSP00000437091
ENST00000471623	ENSP00000434674
ENST00000470212
ENST00000469810
ENST00000497120
ENST00000481528
ENST00000481133
ENST00000484723	ENSP00000435256
ENST00000473856	ENSP00000432328
ENST00000470626	ENSP00000434367
ENST00000528457	ENSP00000432475
ENST00000527941	ENSP00000436810
ENST00000531722	ENSP00000435700
ENST00000528642	ENSP00000433486
ENST00000524582	ENSP00000435568

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016779	nucleotidyltransferase activity
GO:0044822	poly(A) RNA binding
GO:0050265	RNA uridylyltransferase activity

Biological Process

GO:0001816	cytokine production
GO:0008152	metabolic process
GO:0010586	miRNA metabolic process
GO:0010587	miRNA catabolic process
GO:0019827	stem cell maintenance
GO:0031054	pre-miRNA processing
GO:0031123	RNA 3'-end processing
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034610

View Gene Order

ENSBTAG00000002721

Not yet available

Cross-References

SwissProt

TrEMBL

H0YEE8

UniProt Splice Variant

Entrez Gene

23318

UniGene

Hs.609043 Hs.619518 Hs.655407 Hs.717765

RefSeq

NM_001009881 NM_015269 XM_005270680 XM_006710500

HUGO

HGNC:28981

OMIM

613692

CCDS

CCDS30715 CCDS30716

HPRD

15700

IMGT

EMBL

AL138849 AL513218 AL591167

GenPept

RNA Seq Atlas

23318