InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPX7

Summary

InnateDB Protein

IDBP-98649.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPX7

Protein Name

glutathione peroxidase 7

Synonyms

CL683; GPx-7; GPX6; GSHPx-7; NPGPx;

Species

Homo sapiens

Ensembl Protein

ENSP00000354677

InnateDB Gene

IDBG-98647 (GPX7)

Protein Structure

UniProt Annotation

Function

It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269PubMed:22157330}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269PubMed:22157330}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Tissue Specificity

Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids. {ECO:0000269PubMed:22157330}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0004602	glutathione peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006979	response to oxidative stress
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR000889 Glutathione peroxidase
IPR012336 Thioredoxin-like fold
IPR013376 Glutathione peroxidase Gpx7, putative

PFAM

PF00578
PF00255
PF13098
PF13192
PF13462
PF13905

PRINTS

PR01011

PIRSF

PIRSF000303

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt