InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMEM59

Summary

InnateDB Protein

IDBP-98898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMEM59

Protein Name

transmembrane protein 59

Synonyms

C1orf8; HSPC001;

Species

Homo sapiens

Ensembl Protein

ENSP00000234831

InnateDB Gene

IDBG-98894 (TMEM59)

Protein Structure

UniProt Annotation

Function

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269PubMed:20427278, ECO:0000269PubMed:23376921}.

Subcellular Localization

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006914	autophagy
GO:0010508	positive regulation of autophagy
GO:0010955	negative regulation of protein processing
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090285	negative regulation of protein glycosylation in Golgi

Cellular Component

GO:0000137	Golgi cis cisterna
GO:0000138	Golgi trans cisterna
GO:0000139	Golgi membrane
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005797	Golgi medial cisterna
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome