InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSBP3

Summary

InnateDB Protein

IDBP-98974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSBP3

Protein Name

single stranded DNA binding protein 3

Synonyms

CSDP; SSDP; SSDP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000360371

InnateDB Gene

IDBG-98972 (SSBP3)

Protein Structure

UniProt Annotation

Function

May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0008284	positive regulation of cell proliferation
GO:0021501	prechordal plate formation
GO:0021547	midbrain-hindbrain boundary initiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060322	head development
GO:0060323	head morphogenesis
GO:2000744	positive regulation of anterior head development