Version 5.4
Homo sapiens Protein: HOOK1
Summary
InnateDB Protein IDBP-99263.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK1
Protein Name hook homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360252
InnateDB Gene IDBG-99261 (HOOK1)
Protein Structure
UniProt Annotation
Function Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:11238449}. Note=Localizes to the spermatid manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0015630 microtubule cytoskeleton
GO:0030897 HOPS complex
GO:0070695 FHF complex
Protein Structure and Domains
PDB ID
InterPro IPR008636 Hook-related protein family
IPR009053 Prefoldin
PFAM PF05622
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJC3
PhosphoSite PhosphoSite-Q9UJC3
TrEMBL B1AK95
UniProt Splice Variant
Entrez Gene 51361
UniGene Hs.378836
RefSeq NP_056972
HUGO HGNC:19884
OMIM 607820
CCDS CCDS612
HPRD 07428
IMGT
EMBL AC113175 AF044923 AK292314 AK301768 AL035416 BC011621 CH471059
GenPept AAC09298 AAH11621 BAF85003 BAG63227 CAI22779 EAX06615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca