Homo sapiens Gene: HOOK1
Summary
InnateDB Gene IDBG-99261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK1
Gene Name hook homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134709
Encoded Proteins
hook homolog 1 (Drosophila)
hook homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:59814786-59876378
Strand Forward strand
Band p32.1
Transcripts
ENST00000371208 ENSP00000360252
ENST00000455990 ENSP00000398860
ENST00000465876
ENST00000474695
ENST00000466803
ENST00000491135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0015630 microtubule cytoskeleton
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.378836
RefSeq NM_015888 XM_005270922 XM_006710676
HUGO
OMIM
CCDS CCDS612
HPRD 07428
IMGT
EMBL
GenPept
RNA Seq Atlas