InnateDB Protein
|
IDBP-99741.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CRYZ
|
Protein Name
|
crystallin, zeta (quinone reductase)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000359909
|
InnateDB Gene
|
IDBG-99739 (CRYZ)
|
Protein Structure
|
|
Function |
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. {ECO:0000269PubMed:17497241, ECO:0000269PubMed:20103721}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20103721}.
|
Disease Associations |
|
Tissue Specificity |
Only very low amounts in the lens.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
10
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR013149
Alcohol dehydrogenase, C-terminal
IPR020843
Polyketide synthase, enoylreductase
|
PFAM |
PF00107
|
PRINTS |
|
PIRSF |
|
SMART |
SM00829
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q08257
|
PhosphoSite |
PhosphoSite-Q08257
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
1429
|
UniGene |
Hs.83114
|
RefSeq |
NP_001128231
|
HUGO |
HGNC:2419
|
OMIM |
123691
|
CCDS |
CCDS44163
|
HPRD |
00437
|
IMGT |
|
EMBL |
AB209714
AC091611
AC135803
AK223150
AK223201
AK314813
BC039578
BC070058
BX647883
CH471059
L13278
L31521
L31522
L31523
L31524
L31525
L31526
|
GenPept |
AAA36536
AAH39578
AAH70058
AAK40311
BAD92951
BAD96870
BAD96921
CAI46072
EAX06409
EAX06410
EAX06411
EAX06412
|
|
|