Homo sapiens Gene: CRYZ
Summary
InnateDB Gene IDBG-99739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYZ
Gene Name crystallin, zeta (quinone reductase)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116791
Encoded Proteins
crystallin, zeta (quinone reductase)
crystallin, zeta (quinone reductase)
crystallin, zeta (quinone reductase)
crystallin, zeta (quinone reductase)
crystallin, zeta (quinone reductase)
crystallin, zeta (quinone reductase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74705482-74733408
Strand Reverse strand
Band p31.1
Transcripts
ENST00000370872 ENSP00000359909
ENST00000340866 ENSP00000339399
ENST00000370871 ENSP00000359908
ENST00000370870 ENSP00000359907
ENST00000417775 ENSP00000399805
ENST00000441120 ENSP00000404289
ENST00000492102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003730 mRNA 3'-UTR binding
GO:0003960 NADPH:quinone reductase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0070402 NADPH binding
Biological Process
GO:0007601 visual perception
GO:0042178 xenobiotic catabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt Q08257
TrEMBL A6NP24 C9JH92
UniProt Splice Variant
Entrez Gene 1429
UniGene Hs.699602 Hs.83114
RefSeq NM_001130042 NM_001130043 NM_001134759 NM_001889 XM_005270491
HUGO HGNC:2419
OMIM 123691
CCDS CCDS44162 CCDS44163 CCDS665
HPRD
IMGT
EMBL AB209714 AC091611 AC135803 AK223150 AK223201 AK314813 BC039578 BC070058 BX647883 CH471059 L13278 L31521 L31522 L31523 L31524 L31525 L31526
GenPept AAA36536 AAH39578 AAH70058 AAK40311 BAD92951 BAD96870 BAD96921 CAI46072 EAX06409 EAX06410 EAX06411 EAX06412
RNA Seq Atlas 1429