InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRYZ

Summary

InnateDB Protein

IDBP-99743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRYZ

Protein Name

crystallin, zeta (quinone reductase)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339399

InnateDB Gene

IDBG-99739 (CRYZ)

Protein Structure

UniProt Annotation

Function

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. {ECO:0000269PubMed:17497241, ECO:0000269PubMed:20103721}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20103721}.

Disease Associations

Tissue Specificity

Only very low amounts in the lens.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003730	mRNA 3'-UTR binding
GO:0003960	NADPH:quinone reductase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0070402	NADPH binding

Biological Process

GO:0007601	visual perception
GO:0042178	xenobiotic catabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08257