Version 5.4
Bos taurus Gene: EPB49
Summary
InnateDB Gene IDBG-634536.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPB49
Gene Name Dematin
Synonyms EPB49
Species Bos taurus
Ensembl Gene ENSBTAG00000045887
Encoded Proteins
IDBP-686327
Dematin
IDBP-686332
Dematin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158856:
Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:69871349-69896984
Strand Forward strand
Band
Transcripts
ENSBTAT00000065148 ENSBTAP00000054110
ENSBTAT00000066196 ENSBTAP00000054225
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030507 spectrin binding
GO:0043621 protein self-association
Biological Process
GO:0006461 protein complex assembly
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0010591 regulation of lamellipodium assembly
GO:0010763 positive regulation of fibroblast migration
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010812 negative regulation of cell-substrate adhesion
GO:0030036 actin cytoskeleton organization
GO:0030194 positive regulation of blood coagulation
GO:0032956 regulation of actin cytoskeleton organization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035585 calcium-mediated signaling using extracellular calcium source
GO:0048821 erythrocyte development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051017 actin filament bundle assembly
GO:0051489 regulation of filopodium assembly
GO:0051693 actin filament capping
GO:0051895 negative regulation of focal adhesion assembly
GO:0070560 protein secretion by platelet
GO:0071277 cellular response to calcium ion
GO:0071320 cellular response to cAMP
GO:0090303 positive regulation of wound healing
GO:0090315 negative regulation of protein targeting to membrane
GO:0090527 actin filament reorganization
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901731 positive regulation of platelet aggregation
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030863 cortical cytoskeleton
GO:0031095 platelet dense tubular network membrane
GO:0031253 cell projection membrane
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158856
View Gene Order
ENSMUSG00000022099
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.33159
RefSeq NM_001034431
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca