InnateDB: Systems Biology of the Innate Immune Response

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131653:
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:24508562-24527938

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000070777	ENSMUSP00000069334
ENSMUST00000088464	ENSMUSP00000085812
ENSMUST00000177193	ENSMUSP00000135288
ENSMUST00000176086	ENSMUSP00000135845
ENSMUST00000176178	ENSMUSP00000134808
ENSMUST00000175698	ENSMUSP00000135456
ENSMUST00000176530
ENSMUST00000177154	ENSMUSP00000135874
ENSMUST00000177025	ENSMUSP00000135583
ENSMUST00000177405	ENSMUSP00000135127
ENSMUST00000176434
ENSMUST00000177024
ENSMUST00000176361
ENSMUST00000175732
ENSMUST00000176324	ENSMUSP00000135339
ENSMUST00000176092
ENSMUST00000176900
ENSMUST00000176668	ENSMUSP00000135586
ENSMUST00000177401	ENSMUSP00000135341
ENSMUST00000177139
ENSMUST00000177502	ENSMUSP00000134970
ENSMUST00000176237	ENSMUSP00000134946
ENSMUST00000176652	ENSMUSP00000134759
ENSMUST00000176633
ENSMUST00000176805
ENSMUST00000176353	ENSMUSP00000135267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:0043410	positive regulation of MAPK cascade
GO:0097194	execution phase of apoptosis
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000131653

View Gene Order

ENSBTAG00000019073

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.275150 Mm.416156

RefSeq

NM_001172113 NM_001172114 NM_153792

OMIM

CCDS

CCDS50014 CCDS50015

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas