Homo sapiens Gene: SDHA
Summary
InnateDB Gene IDBG-10076.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol SDHA
Gene Name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms CMD1GG; FP; PGL5; SDH1; SDH2; SDHF;
Species Homo sapiens
Ensembl Gene ENSG00000073578
Encoded Proteins
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Protein Structure
Entrez Gene
Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:218356-256815
Strand Forward strand
Band p15.33
Transcripts
ENST00000264932 ENSP00000264932
ENST00000504309 ENSP00000426514
ENST00000506138
ENST00000502379
ENST00000505555
ENST00000510361 ENSP00000427703
ENST00000509632 ENSP00000425077
ENST00000504824
ENST00000509420
ENST00000514027
ENST00000514233
ENST00000512962
ENST00000515752
ENST00000511810
ENST00000515815 ENSP00000422404
ENST00000509082
ENST00000503674
ENST00000507266
ENST00000512951
ENST00000509564 ENSP00000421911
ENST00000507522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000104 succinate dehydrogenase activity
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006105 succinate metabolic process
GO:0007399 nervous system development
GO:0022900 electron transport chain
GO:0022904 respiratory electron transport chain
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005749 mitochondrial respiratory chain complex II
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Respiratory electron transport pathway
Citric acid cycle (TCA cycle) pathway
KEGG
Parkinson`s disease pathway
Metabolic pathways pathway
Huntington`s disease pathway
Oxidative phosphorylation pathway
Citrate cycle (TCA cycle) pathway
Alzheimer`s disease pathway
INOH
Arginine Proline metabolism pathway
Tyrosine metabolism pathway
Citrate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P31040
TrEMBL B3KT34 D6REB7 D6RFM5 E9PBJ5 H0Y8S2 Q0QF12
UniProt Splice Variant
Entrez Gene 6389
UniGene Hs.440475 Hs.607328
RefSeq NM_004168
HUGO 10680
OMIM 600857
CCDS CCDS3853
HPRD 02914
IMGT
EMBL AC021087 AF171017 AF171018 AF171019 AF171020 AF171021 AF171022 AF171023 AF171024 AF171025 AF171026 AF171027 AF171028 AF171029 AF171030 AK094879 AK291311 BC001380 CH471235 D30648 DQ402982 L21936 S79641 X53943
GenPept AAA20683 AAB35332 AAD51006 AAH01380 ABD77315 BAA06332 BAF84000 BAG52946 CAA37886 EAW50983
ImmGen SDHA (murine)
RNA Seq Atlas 6389