Homo sapiens Gene: SDHA

Summary
InnateDB Gene IDBG-10076.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol SDHA
Gene Name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms CMD1GG; FP; PGL5; SDH1; SDH2; SDHF
Species Homo sapiens
Ensembl Gene ENSG00000073578
Encoded Proteins
IDBP-10082 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
IDBP-482753 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
IDBP-478100 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
IDBP-483387 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
IDBP-481817 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
IDBP-484959 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Entrez Gene
Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5: 218356-256815
Strand Forward strand
Band p15.33
Transcripts
ENST00000264932  ENSP00000264932
ENST00000504309  ENSP00000426514
ENST00000506138 
ENST00000502379 
ENST00000505555 
ENST00000510361  ENSP00000427703
ENST00000509632  ENSP00000425077
ENST00000504824 
ENST00000509420 
ENST00000514027 
ENST00000514233 
ENST00000512962 
ENST00000515752 
ENST00000511810 
ENST00000515815  ENSP00000422404
ENST00000509082 
ENST00000503674 
ENST00000507266 
ENST00000512951 
ENST00000509564  ENSP00000421911
ENST00000507522 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein‑Protein  7
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 2 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0000104 succinate dehydrogenase activity
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006105 succinate metabolic process
GO:0007399 nervous system development
GO:0022900 electron transport chain
GO:0022904 respiratory electron transport chain
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005749 mitochondrial respiratory chain complex II
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000021577 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000046019 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_1785 Citric acid cycle (TCA cycle)
REACT_22393 Respiratory electron transport
KEGG
hsa05010  Alzheimer`s disease
hsa00020  Citrate cycle (TCA cycle)
hsa05016  Huntington`s disease
hsa01100  Metabolic pathways
hsa00190  Oxidative phosphorylation
hsa05012  Parkinson`s disease
INOH
INOH website Citrate cycle
INOH website Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol - Arginine and Proline metabolism
INOH website Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol - Citrate cycle
INOH website Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol - Tyrosine metabolism
PID BIOCARTA
PID NCI
Citric_acid_cycle__TCA_cycle_ Citric acid cycle (TCA cycle)
Respiratory_electron_transport Respiratory electron transport
Cross-References
SwissProt P31040 
TrEMBL B3KT34 D6REB7 D6RFM5 E9PBJ5 H0Y8S2 Q0QF12
UniProt Splice Variant
Entrez Gene 6389 
UniGene Hs.440475 Hs.607328
RefSeq NM_004168 
HUGO 10680 
OMIM 600857
CCDS CCDS3853 
HPRD 02914
IMGT
EMBL AC021087 AF171017 AF171018 AF171019 AF171020 AF171021 AF171022 AF171023 AF171024 AF171025 AF171026 AF171027 AF171028 AF171029 AF171030 AK094879 AK291311 BC001380 CH471235 D30648 DQ402982 L21936 S79641 X53943
GenPept AAA20683  AAB35332  AAD51006  AAH01380  ABD77315  BAA06332  BAF84000  BAG52946  CAA37886  EAW50983 
ImmGen SDHA (murine) 
RNA Seq Atlas 6389