InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sdha

Summary

InnateDB Gene

IDBG-167329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdha

Gene Name

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Synonyms

1500032O14Rik; 2310034D06Rik; 4921513A11; C81073; FP; SDH2; SDHF

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021577

Encoded Proteins

IDBP-167331

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073578:
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. [provided by RefSeq, Jul 2008]
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:74322254-74350280

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022062	ENSMUSP00000022062
ENSMUST00000161434
ENSMUST00000160900
ENSMUST00000160667
ENSMUST00000161086
ENSMUST00000160400
ENSMUST00000162137
ENSMUST00000161456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000104	succinate dehydrogenase activity
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (ubiquinone) activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0007399	nervous system development
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain
GO:0055114	oxidation-reduction process