InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF13

Summary

InnateDB Gene

IDBG-100762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF13

Gene Name

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa

Synonyms

TAF(II)18; TAF2K; TAFII-18; TAFII18

Species

Homo sapiens

Ensembl Gene

ENSG00000197780

Encoded Proteins

IDBP-100766

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa

IDBP-599129

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:109062486-109076002

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000338366	ENSP00000355051
ENST00000461096	ENSP00000433883

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process