Homo sapiens Gene: GNAT2

Summary
InnateDB Gene IDBG-100852.4
Last Modified 2011-02-17   [Report errors or provide feedback]
Gene Symbol GNAT2
Gene Name guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Synonyms ACHM4; GNATC
Species Homo sapiens
Ensembl Gene ENSG00000134183
Encoded Proteins
IDBP-100854 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Entrez Gene
Summary Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 110145889-110155679
Strand Reverse strand
Band p13.3
Transcripts
ENST00000351050  ENSP00000251337
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein‑Protein  4
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0009642 response to light intensity
GO:0046549 retinal cone cell development
GO:0050908 detection of light stimulus involved in visual perception
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0031234 extrinsic to internal side of plasma membrane
GO:0042622 photoreceptor outer segment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000009108 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000013017 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_19231 G alpha (i) signalling events
REACT_15457 G-protein activation
REACT_15426 PLC beta mediated events
KEGG
hsa04744  Phototransduction
INOH
PID BIOCARTA
PID NCI
cone_pathway Visual signal transduction: Cones
Cross-References
SwissProt P19087 
TrEMBL Q16162 Q5T697
UniProt Splice Variant
Entrez Gene 2780 
UniGene Hs.36973
RefSeq NM_005272 
HUGO 4394 
OMIM 139340
CCDS CCDS803 
HPRD 00762
IMGT
EMBL AF493909 AL355310 BC000233 BT009844 CH471122 D10384 S70567 Z18859
GenPept AAD14063  AAH00233  AAM12623  AAP88846  BAA01211  CAA79310  CAI19304  EAW56394 
ImmGen GNAT2 (murine) 
RNA Seq Atlas 2780