Homo sapiens Gene: GNAT2
Summary
InnateDB Gene IDBG-100852.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNAT2
Gene Name guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Synonyms ACHM4; GNATC;
Species Homo sapiens
Ensembl Gene ENSG00000134183
Encoded Proteins
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Protein Structure
Entrez Gene
Summary Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:109603267-109619929
Strand Reverse strand
Band p13.3
Transcripts
ENST00000351050 ENSP00000251337
ENST00000622865 ENSP00000482596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0009642 response to light intensity
GO:0046549 retinal cone cell development
GO:0050908 detection of light stimulus involved in visual perception
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0042622 photoreceptor outer segment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
PLC beta mediated events pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
G-protein activation pathway
G-protein mediated events pathway
KEGG
Phototransduction pathway
INOH
PID BIOCARTA
PID NCI
Visual signal transduction: Cones
Cross-References
SwissProt P19087
TrEMBL Q16162 Q5T697
UniProt Splice Variant
Entrez Gene 2780
UniGene Hs.36973
RefSeq NM_005272
HUGO HGNC:4394
OMIM 139340
CCDS CCDS803
HPRD 00762
IMGT
EMBL AF493909 BC000233 BT009844 CH471122 D10384 S70567 Z18859
GenPept AAD14063 AAH00233 AAM12623 AAP88846 BAA01211 CAA79310 EAW56394 EAW56395
ImmGen GNAT2 (murine)
RNA Seq Atlas 2780