InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gnat2

Summary

InnateDB Gene

IDBG-186203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnat2

Gene Name

guanine nucleotide binding protein, alpha transducing 2

Synonyms

AW490837; Gnat-2; Gt-2; Tcalpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009108

Encoded Proteins

IDBP-186205

guanine nucleotide binding protein, alpha transducing 2

IDBP-539558

guanine nucleotide binding protein, alpha transducing 2

IDBP-539952

guanine nucleotide binding protein, alpha transducing 2

IDBP-537186

guanine nucleotide binding protein, alpha transducing 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134183:
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:108092789-108101432

Strand

Forward strand

Band

F2.3

Transcripts

ENSMUST00000058669	ENSMUSP00000053818
ENSMUST00000145101	ENSMUSP00000123125
ENSMUST00000151326	ENSMUSP00000120425
ENSMUST00000142568
ENSMUST00000131856	ENSMUSP00000121533
ENSMUST00000130013

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0009642	response to light intensity
GO:0016056	rhodopsin mediated signaling pathway
GO:0046549	retinal cone cell development
GO:0050908	detection of light stimulus involved in visual perception

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane