Version 5.4
Homo sapiens Gene: HBXIP
Summary
InnateDB Gene IDBG-100979.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBXIP
Gene Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms HBXIP; XIP
Species Homo sapiens
Ensembl Gene ENSG00000134248
Encoded Proteins
IDBP-100983
hepatitis B virus x interacting protein
IDBP-585791
hepatitis B virus x interacting protein
IDBP-595773
hepatitis B virus x interacting protein
IDBP-808553
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
IDBP-808556
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
IDBP-808557
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:110401249-110407942
Strand Reverse strand
Band p13.3
Transcripts
ENST00000256644 ENSP00000256644
ENST00000464240
ENST00000474861 ENSP00000434828
ENST00000483260 ENSP00000435085
ENST00000531779
ENST00000602318 ENSP00000473439
ENST00000602858 ENSP00000473357
ENST00000614544 ENSP00000480529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 19 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0008361 regulation of cell size
GO:0009615 response to virus
GO:0019079 viral genome replication
GO:0032008 positive regulation of TOR signaling
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0061462 protein localization to lysosome
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0071986 Ragulator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000087260
View Gene Order
ENSBTAG00000014970
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL R4GMU8
UniProt Splice Variant
Entrez Gene 10542
UniGene
RefSeq NM_006402
HUGO HGNC:17955
OMIM 608521
CCDS CCDS824
HPRD
IMGT
EMBL AL390797
GenPept
RNA Seq Atlas 10542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca