InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNA2

Summary

InnateDB Gene

IDBG-100992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNA2

Gene Name

potassium voltage-gated channel, shaker-related subfamily, member 2

Synonyms

HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2

Species

Homo sapiens

Ensembl Gene

ENSG00000177301

Encoded Proteins

IDBP-100994

potassium voltage-gated channel, shaker-related subfamily, member 2

IDBP-100996

potassium voltage-gated channel, shaker-related subfamily, member 2

IDBP-590644

potassium voltage-gated channel, shaker-related subfamily, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:110593580-110631474

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000369770	ENSP00000358785
ENST00000316361	ENSP00000314520
ENST00000485317	ENSP00000433109
ENST00000525120

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0021633	optic nerve structural organization
GO:0034765	regulation of ion transmembrane transport
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0044224	juxtaparanode region of axon

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040724

View Gene Order

ENSBTAG00000015459

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.248139 Hs.657199 Hs.731191

RefSeq

NM_001204269 NM_004974

HUGO

OMIM

CCDS

CCDS55625 CCDS827

HPRD

01443

IMGT

EMBL

GenPept

RNA Seq Atlas