Version 5.4
Homo sapiens Gene: RHOC
Summary
InnateDB Gene IDBG-101162.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOC
Gene Name ras homolog family member C
Synonyms ARH9; ARHC; H9; RHOH9
Species Homo sapiens
Ensembl Gene ENSG00000155366
Encoded Proteins
IDBP-101164
ras homolog gene family, member C
IDBP-101166
ras homolog gene family, member C
IDBP-101168
ras homolog gene family, member C
IDBP-101170
ras homolog gene family, member C
IDBP-101172
ras homolog gene family, member C
IDBP-101174
ras homolog gene family, member C
IDBP-101176
ras homolog gene family, member C
IDBP-101178
ras homolog gene family, member C
IDBP-387762
ras homolog gene family, member C
IDBP-387764
ras homolog gene family, member C
IDBP-387765
ras homolog gene family, member C
IDBP-593006
ras homolog gene family, member C
IDBP-599907
ras homolog gene family, member C
IDBP-603703
ras homolog gene family, member C
IDBP-597325
ras homolog gene family, member C
IDBP-590298
ras homolog gene family, member C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:112701106-112707434
Strand Reverse strand
Band p13.2
Transcripts
ENST00000339083 ENSP00000345236
ENST00000369642 ENSP00000358656
ENST00000285735 ENSP00000285735
ENST00000369638 ENSP00000358652
ENST00000369637 ENSP00000358651
ENST00000369636 ENSP00000358650
ENST00000369633 ENSP00000358647
ENST00000369632 ENSP00000358646
ENST00000425265 ENSP00000390823
ENST00000436685 ENSP00000399424
ENST00000414971 ENSP00000395791
ENST00000468093 ENSP00000431392
ENST00000473074
ENST00000484280 ENSP00000434310
ENST00000484054 ENSP00000434877
ENST00000478447
ENST00000534717 ENSP00000436240
ENST00000528831 ENSP00000432209
ENST00000527563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0000910 cytokinesis
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0015031 protein transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297 apical junction assembly
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032154 cleavage furrow
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002233
View Gene Order
ENSBTAG00000014299
Not yet available
Pathways
NETPATH
REACTOME
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
PID NCI
prlsignalingeventspathway
Signaling events mediated by PRL
Cross-References
SwissProt
TrEMBL E9PQH6 Q5JR06 Q5JR07
UniProt Splice Variant
Entrez Gene 389
UniGene Hs.502659
RefSeq NM_001042678 NM_001042679 NM_175744
HUGO HGNC:669
OMIM 165380
CCDS CCDS854
HPRD 01322
IMGT
EMBL AL603832
GenPept
RNA Seq Atlas 389

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca