InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RHOC

Summary

InnateDB Gene

IDBG-634972.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOC

Gene Name

Rho-related GTP-binding protein RhoC

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014299

Encoded Proteins

IDBP-686769

Rho-related GTP-binding protein RhoC

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155366:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:30769966-30776469

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018998

ENSBTAP00000018998

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297	apical junction assembly