Version 5.4
Homo sapiens Gene: TPM3
Summary
InnateDB Gene IDBG-102860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPM3
Gene Name tropomyosin 3
Synonyms CAPM1; CFTD; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK
Species Homo sapiens
Ensembl Gene ENSG00000143549
Encoded Proteins
IDBP-102864
tropomyosin 3
IDBP-102866
tropomyosin 3
IDBP-102872
tropomyosin 3
IDBP-102874
tropomyosin 3
IDBP-102876
tropomyosin 3
IDBP-102878
tropomyosin 3
IDBP-102882
tropomyosin 3
IDBP-102884
tropomyosin 3
IDBP-102886
tropomyosin 3
IDBP-102888
tropomyosin 3
IDBP-480107
tropomyosin 3
IDBP-477494
tropomyosin 3
IDBP-484914
tropomyosin 3
IDBP-806996
tropomyosin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154155304-154194648
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368545
ENST00000341485 ENSP00000341653
ENST00000368533 ENSP00000357521
ENST00000312970
ENST00000341372 ENSP00000339378
ENST00000328159 ENSP00000357520
ENST00000323144 ENSP00000357518
ENST00000302206 ENSP00000307712
ENST00000330188 ENSP00000339035
ENST00000368531 ENSP00000357517
ENST00000368530 ENSP00000357516
ENST00000271850 ENSP00000271850
ENST00000368527
ENST00000469717
ENST00000509409 ENSP00000426521
ENST00000513769
ENST00000504663
ENST00000509601 ENSP00000422207
ENST00000505010
ENST00000473036
ENST00000466010
ENST00000515609 ENSP00000426306
ENST00000611659 ENSP00000480520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
Biological Process
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0030049 muscle filament sliding
Cellular Component
GO:0001725 stress fiber
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005862 muscle thin filament tropomyosin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027940
View Gene Order
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05216
Thyroid cancer pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.625550 Hs.644306 Hs.715250
RefSeq NM_001043351 NM_001043352 NM_001043353 NM_001278188 NM_001278189 NM_001278190 NM_001278191 NM_152263 NM_153649 XM_006711516 XM_006711517 XM_006711518 XM_006711523
HUGO
OMIM
CCDS CCDS1060 CCDS41400 CCDS41401 CCDS41402 CCDS41403 CCDS60274 CCDS60275 CCDS72922
HPRD 01840
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca