Version 5.4
Homo sapiens Gene: PYGO2
Summary
InnateDB Gene IDBG-103002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYGO2
Gene Name pygopus homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163348
Encoded Proteins
IDBP-103004
pygopus homolog 2 (Drosophila)
IDBP-103006
pygopus homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154957026-154963853
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368457 ENSP00000357442
ENST00000368456 ENSP00000357441
ENST00000483463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035034 histone acetyltransferase regulator activity
GO:0042393 histone binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0002088 lens development in camera-type eye
GO:0007286 spermatid development
GO:0007289 spermatid nucleus differentiation
GO:0007420 brain development
GO:0009791 post-embryonic development
GO:0016055 Wnt signaling pathway
GO:0030879 mammary gland development
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0035065 regulation of histone acetylation
GO:0035563 positive regulation of chromatin binding
GO:0048589 developmental growth
GO:0051569 regulation of histone H3-K4 methylation
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047824
View Gene Order
ENSBTAG00000004331
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533597
RefSeq NM_138300
HUGO
OMIM
CCDS CCDS1075
HPRD 06065
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca