Version 5.4
Homo sapiens Gene: SH2D2A
Summary
InnateDB Gene IDBG-103627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D2A
Gene Name SH2 domain containing 2A
Synonyms F2771; SCAP; TSAD; VRAP
Species Homo sapiens
Ensembl Gene ENSG00000027869
Encoded Proteins
IDBP-103629
SH2 domain containing 2A
IDBP-103631
SH2 domain containing 2A
IDBP-245927
SH2 domain containing 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156806243-156816862
Strand Reverse strand
Band q23.1
Transcripts
ENST00000368199 ENSP00000357182
ENST00000368198 ENSP00000357181
ENST00000392306 ENSP00000376123
ENST00000468744
ENST00000486350
ENST00000495306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0009967 positive regulation of signal transduction
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028071
View Gene Order
ENSBTAG00000024470
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
KEGG
hsa04370
VEGF signaling pathway pathway
INOH
INOH website
VEGF signaling pathway pathway
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.103527
RefSeq NM_001161441 NM_001161442 NM_001161443 NM_001161444 NM_003975 XM_006711615
HUGO
OMIM
CCDS CCDS1159 CCDS53380 CCDS53381
HPRD 05152
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca